Plasmid Transfer of Plasminogen K1-5 Reduces Subcutaneous Hepatoma Growth by Affecting Inflammatory Factors
Figure 7
In vivo effects of pK1-5 on VEGF expression. Mice with subcutaneous tumours were treated with NaCl ( = 5), DOTAP ( = 6), pMock ( = 6), or pK1-5 ( = 5) and sacrificed after ten days. Tumours and livers were explanted and homogenized, serum was collected, and protein concentrations were evaluated. VEGF levels were quantified with a murine VEGF ELISA. Data are presented as mean pg VEGF ± SEM. < 0.05 (compared to NaCl). (a) Tumour samples, (b) liver samples, and (c) tumour sections were stained against VEGF and counterstained with hematoxyline. Exemplary photomicrographs of animals treated with NaCl, DOTAP, pMock, and pK1-5. VEGF is shown by brown staining.
