Research Article
Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats
Table 1
Age-related effect on basic biometric and vascular parameters of the femoral artery of juvenile and young adult Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).
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ACh: acetylcholine; BW: body weight; BP: blood pressure; E max ACh: maximal acetylcholine-induced relaxation based on individual concentration-response curves; : maximal acetylcholine-induced relaxation after L-NAME based on individual concentration-response curves; : maximal sodium nitroprusside-induced relaxation based on individual concentration-response curves; HR: heart rate; KPSS: high-potassium physiological salt solution; L-NAME: NG-nitro-L-arginine methyl ester; LVW: left heart ventricle weight; ND: normalized diameter of the femoral artery at 13.3 kPa calculated within the normalization procedure; Ser: vascular constriction induced by serotonin (1 mol/L); SerL-NAME: vascular constriction induced by serotonin (1 mol/L) after L-NAME; SNP: sodium nitroprusside. Results are mean ± S.E.M. of 6–10 rats. x compared to age-matched WKY (SHR-7 versus WKY-7, SHR-22 versus WKY-22), * compared to juvenile rats (WKY-22 versus WKY-7, SHR-22 versus SHR-7), and † compared to the respective value before L-NAME. |