BioMed Research International / 2014 / Article / Tab 1 / Review Article
Role of Circulating Lymphocytes in Patients with Sepsis Table 1 Main lymphocyte types’ alterations in sepsis.
Lymphocyte type Roles Outcomes in sepsis References CD4+ T cells : positive feedback on antigen presenting cells. : promoting downregulation.Lack of a shift from to increases survival. [35 ] : producing IL-17, IL-21, TNF- , and IFN- . lymphocyte count in survivors was higher. [52 ] Treg: immunosuppressive activity. Treg lymphocyte counts higher in surviving patients [41 ] CD8+ T cells Effector cytotoxic cells. In survivors, CD8+ T lymphocytes showed a further drop on day 3 of follow-up. [36 ] NK cells Effector cytotoxic activity and immunoregulatory function. CD69+, an activation marker, increases in nonsurvivors. CD57+, a marker of long-lived and differentiated NK cells, shows higher percentage in nonsurvivors. [72 ] B cells Ability to differentiate into immunoglobulin secreting plasma cells. An inverse correlation between count and survival, but this relation affects heterogeneously the subsets. [23 , 101 ]
Abbreviations: TH : T helper; IL: interleukin; TNF: tumor necrosis factor; IFN: interferon.