Emergent Bacteria in Cystic Fibrosis: In Vitro Biofilm Formation and Resilience under Variable Oxygen Conditions

Table 1

In vitro antibiotic susceptibilities of planktonic and biofilm populations formed by P. aeruginosa (PA), I. limosus (IL), and D. pigrum (DP) under aerobic, microaerophilic, and anaerobic environments.

Antibiotic	Aerobic			Microaerophilic			Anaerobic
	PA	IL	DP	PA	IL	DP	PA	IL	DP
Tobramycin
MIC^a	≤2	64	512	≤2	128	64	≤2	64	64
MBEC	>1024	>1024	>1024	64	>1024	>1024	512	>1024	>1024
Gentamicin
MIC	≤2	8	512	≤2	16	16	≤2	16	32
MBEC	>1024	>1024	>1024	128	>1024	>1024	1024	>1024	512
Levofloxacin
MIC	≤2	≤2	512	≤2	≤2	16	≤2	≤2	16
MBEC	>1024	>1024	>1024	256	>1024	>1024	16	>1024	>1024
Ciprofloxacin
MIC	≤2	≤2	>1024	≤2	≤2	16	≤2	≤2	32
MBEC	128	>1024	>1024	128	>1024	>1024	128	>1024	>1024
Clindamycin
MIC	>1024	16	512	>1024	64	4	>1024	16	4
MBEC	>1024	>1024	>1024	>1024	>1024	>1024	>1024	>1024	>1024
Cefotaxime
MIC	128	256	512	32	512	8	32	128	8
MBEC	>1024	>1024	>1024	>1024	>1024	>1024	>1024	>1024	>1024
Chloramphenicol
MIC	512	256	256	64	128	8	64	128	16
MBEC	>1024	>1024	>1024	>1024	>1024	>1024	>1024	>1024	>1024
Rifampicin
MIC	512	8	1024	>1024	≤2	≤2	>1024	≤2	≤2
MBEC	>1024	256	512	>1024	>1024	>1024	>1024	>1024	64

^aMIC and MBEC values are expressed in mg/L.