Network Analysis of Neurodegenerative Disease Highlights a Role of Toll-Like Receptor Signaling

Table 2

The top 20 proteins ranked by four network indices.

Rank	Uniprot ID	𝐷	Uniprot ID	𝐶	Uniprot ID	𝐵	Uniprot ID	TI^3
1	P04626	133	P10636	0,000283	P04626	138806,9	P04626	223,9606
2	P20226	125	P62993	0,000277	P20226	124955,9	P20226	191,1601
3	P04156	83	P37840	0,000273	P04156	112084,5	P04156	140,9858
4	Q16637	82	P20226	0,000273	P37840	91931,3	Q16637	140,258
5	P55072	78	P04626	0,00027	Q16637	89120,94	P55072	121,1479
6	P37840	72	Q14203	0,000267	P55072	84506,5	P49768	101,3766
7	O60260	67	P62988	0,000267	P62993	83655,6	P42858	99,16651
8	P49768	67	P04156	0,000266	P10636	78425,93	P37840	96,52639
9	P42858	64	P42858	0,000266	P42858	77523,24	O60260	95,05239
10	P10636	58	P49768	0,000261	P49768	67333,14	P37231	88,60983
11	P37231	57	P09936	0,00026	O60260	62325,74	P01023	84,57448
12	Q14203	51	P55072	0,00026	P01023	62196,92	Q14203	82,81538
13	P35637	49	P35637	0,000258	P37231	58762,26	P10636	71,14661
14	P01023	47	P51587	0,000258	Q14203	55777,51	P35637	70,99781
15	P21675	44	O60260	0,000256	P51587	51505,59	P51587	64,43589
16	P51587	42	Q16637	0,000249	P62988	49875,5	P21675	52,16238
17	P22314	31	Q9UNE7	0,000247	P35637	46745,78	Q6Y7W6	46,97096
18	Q6Y7W6	30	P21675	0,000247	Q6Y7W6	38551,43	P43354	41,79592
19	P43354	28	P05067	0,000247	P05067	37130,13	P22314	41,70855
20	P09936	26	P37231	0,000247	P09936	29961,11	P28799	32,43995

The “gene symbol” column shows the corresponding genes of top 20 proteins (in UniprotID) ranked by degree values.