Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain
Figure 2
Thermal (a) and mechanical (b) allodynia and thermal hyperalgesia (c) in intact or CCI animals at 3, 7, and 14 days after CCI of the sciatic nerve. Thermal allodynia and hyperalgesia were measured as thermal withdrawal latency in seconds (mean ± SEM) and mechanical allodynia as mechanical withdrawal threshold in grams (mean ± SEM). Cut-off values were 30 s, 26 g, and 20 s for the cold plate, von Frey’s and Hargreaves’ tests, respectively. Statistical analysis was performed using a one-way ANOVA followed by Bonferroni post hoc tests. Values with were considered significant. * denotes significant difference versus intact and # versus contralateral paw.
