Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology

Table 1

Independent variables along with their coded level, actual level, and respective responses values of different batches of ERY-SLNs.

Form. code	Coded level		Actual level		Responses
	𝑋1	𝑋2	𝑋1	𝑋2	Mean particle size; (nm)	Polydispersity; index; (PDI)	Zeta Potential; (mV)	EE; (%)	DL; (%)
SLN 1	−1	−1	15	01 : 02	193.16±18.49	0.024±0.002	−7.54±(−1.41)	84.96±4.17	28.32±1.39
SLN 2	−1	0	15	01 : 01	119.86±6.54	0.075±0.030	−15.18±(−5.53)	91.72±0.98	30.57±0.32
SLN 3	−1	1	15	02 : 01	255.73±22.68	0.042±0.028	−11.11±(−3.20)	81.14±1.94	27.04±0.64
SLN 4	0	−1	20	01 : 02	358.20±27.00	0.352±0.059	−11.61±(−1.46)	87.60±0.93	21.89±0.23
SLN 5	0	0	20	01 : 01	321.46±17.99	0.195±0.057	−8.87±(−3.78)	93.39±3.90	23.34±0.97
SLN 6	0	1	20	02 : 01	389.20±33.34	0.419±0.090	−16.26±(−1.89)	84.55±1.57	21.13±0.39
SLN 7	1	−1	25	01 : 02	451.00±38.00	0.286±0.056	−14.56±(−6.03)	90.78±1.46	18.15±0.29
SLN 8	1	0	25	01 : 01	434.06±21.43	0.208±0.079	−10.23±(−6.77)	94.27±2.98	18.85±0.60
SLN 9	1	1	25	02 : 01	526.50±25.12	0.458±0.124	−19.57±(−4.76)	89.72±2.81	18.20±0.19