Research Article
Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology
Table 3
Summary of results of regression analysis for responses and analysis of variance for particle size, EE, and DL.
| Parameters | DF | SS | MS | | value | | SD | Coeff. of variance % |
| Mean particle size | Model | 5 | | 26902.5 | 49.04 | 0.0045 significant | 0.9879 | 23.42 | 6.91 | Residual | 3 | 1645.67 | 548.56 | | | | | | Total | 8 | | | | | | | |
|
%Entrapment efficiency | Model | 5 | 149.33 | 29.87 | 11.56 | 0.0356 significant | 0.9507 | 1.61 | 1.81 | Residual | 3 | 7.75 | 2.58 | | | | | | Total | 8 | 157.08 | | | | | | |
| %Drug loading | Model | 5 | 168.89 | 33.78 | 61.66 | 0.0032 significant | 0.9904 | 0.74 | 3.21 | Residual | 3 | 1.64 | 0.55 | | | | | | Total | 8 | 170.53 | | | | | | |
|
|