A Systematic Follow-Up of Mycobacterium tuberculosis Drug-Resistance and Associated Genotypic Lineages in the French Departments of the Americas over a Seventeen-Year Period

Table 1

Characteristics of the 1239 patients and the corresponding M. tuberculosis isolates; data on cases of resistant and multiresistant TB are specified in the respective columns.

Variables	Resistant TB (𝑛=153; 12.3%)		MDR-TB (𝑛=26; 2.1%)		𝑁 total^a (%) (𝑛=1239)
	𝑁 (%)	𝑃	𝑁 (%)	𝑃
Gender
Male	101 (66.5)	0.651	13 (50.0)	0.147	786 (64.4)
Female	51 (33.5)		13 (50.0)		434 (35.6)
Unknown ^b	1		0		19
Age
<15 years	7 (4.8)	0.331	0	0.912	46 (3.9)
15–65 years	126 (85.7)		23 (88.5)		982 (82.9)
>65 years	14 (9.5)		3 (11.5)		156 (13.2)
Unknown ^b	6		0		55
Mean age	41.2	0.724	40.9	0.715	42.6
Origin^c
Guadeloupe	39 (25.5)	0.755	8 (30.8)	0.331	346 (27.9)
Martinique	23 (15.0)		1 (3.9)		177 (14.3)
French Guiana	91 (59.5)		17 (65.4)		716 (57.8)
HIV status
Positive	33 (51.6)	0.506	13 (65.0)	0.117	243 (47.5)
Negative	31 (48.4)		7 (35.0)		269 (52.5)
Unknown ^b	89		6		727
Bacteriology^d
Smear +/culture+	77 (53.5)	0.530	17 (65.4)	0.425	646 (56.2)
Smear −/culture+	67 (46.5)		9 (34.6)		503 (43.8)
Unknown ^b	9		0		90
Case characteristic
Persistent	11 (7.2)	0.007	7 (26.9)	<0.001	40 (3.2)
New case	142 (92.8)		19 (73.1)		1199 (96.8)
Lineage^d
LAM	38 (24.8)	0.060	11 (42.3)	0.470	294 (23.7)
H	27 (17.7)		5 (19.2)		275 (22.2)
T	39 (25.5)		7 (26.9)		373 (30.1)
EAI	10 (6.5)		1 (3.9)		89 (7.2)
X	16 (10.5)		1 (3.9)		81 (6.5)
Others	23 (15.0)		1 (3.9)		127 (10.3)

aN_total: total number of patients per variable.
bNumber of patients/isolates for which this information was not available (excluded from calculations).
cDepartment where a given M. tuberculosis isolate has been obtained.
dLAM: Latin-American-Mediterranean; H: Haarlem; EAI: East-African-Indian; others: lineages/MTBC members accounting for <1.5% of the isolates (M. africanum, Beijing, M. bovis, CAS: Central-Asian, LAM10-CAM, LAM7-TUR, S) and phylogenetically undefined spoligotype profiles.