Review Article
The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions
Table 1
Effects of exosomes vesicles on cell target.
| Vesicles source | Isolation methods | Cell target | Biological function | Effect | References |
| Cytotrophoblast cells | UT + sucrose continuous gradient | EVT (HTR-8/Svneo) | Invasion and proliferation | Promote | [65] | pMSC | UT + 30% sucrose cushion | hPMEC | Migration and proliferation | Promote | [58] | Maternal plasma | UT + sucrose continuous gradient | HUVEC | Migration | Promote | [64] | Trophoblast (Swan 71) | UT | Monocytes | Migration | Promote | [54] | Chorionic villi explant | UT + sucrose continuous gradient | Jurkat T cells and PBMC | Apoptosis | Promote | [77] | Trophoblast cells | UT + 30% sucrose cushion | HUVEC | Viral infection | Resistance | [78] | Human macrophages | UT + sucrose continuous gradient | Endothelial cell | Migration | Decrease | [79] | CML cells | UT + 30% sucrose cushion | HUVEC | Migration | Promote | [80] | Dendritic cells | UT + 30% sucrose cushion | PBMC | Migration | Promote | [81] | Pancreatic adenocarcinoma cells | UT + sucrose continuous gradient | Endothelial cells | Migration | Promote | [82] | HUVEC | UT | SMCs | miRNAs expression | Transfer miRNAs | [83] |
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UT: ultracentrifugation (>100,000 ×g); EVT: extravillous trophoblast; pMSC: placental mesenchymal stem cells; hPMEC: human placental microvascular endothelial cells; HUVEC: human umbilical vein endothelial cells; PBMC: peripheral blood mononuclear cells; CML: chronic myelogenous leukemia; SMCs: smooth muscle cells.
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