ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

<table>Aggrecan cleavage in<i> Adamts4</i>−/− and<i> Adamts5</i>−/− mice following SCI. Aggrecan fragments (~50 and 60 kDa) detected with the anti-NITEGE antibody are seen in wild-type,<i> Adamts4</i>−/−, and<i> Adamts5</i>−/− mice 1 day after SCI (arrows, top panel). Lower molecular weight species (~25 kDa) are also seen in most groups (asterisks, top panel). No aggrecanase activity was detected in sham-operated mice. <i>β</i>-Actin was used as a loading control (bottom panel).</table>

BioMed Research International

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Figure 1

Figure 1: ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury 