ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

<table>Brevican cleavage in<i> Adamts4</i>−/− and<i> Adamts5</i>−/− mice following SCI. Full-length brevican (~145 kDa) and brevican fragments (~50 kDa) detected with the anti-brevican antibody are seen in wild-type,<i> Adamts4</i>−/−, and<i> Adamts5</i>−/− mice 1 and 7 days after SCI (arrows). All groups showed diminished brevican cleavage at 7 days after injury. Minimal brevicanase activity was detected in sham-operated mice.</table>

BioMed Research International

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Figure 3: ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury 