Amelioration of Paracetamol-Induced Hepatotoxicity in Rat by the Administration of Methanol Extract of Muntingia calabura L. Leaves

Table 3

Effect of MEMC on the ALT, AST, and ALP (U/L) level following its pretreatment against the PCM-induced hepatic injury.

Treatment	Dose (mg/kg)	ALT (U/L)	AST (U/L)	ALP (U/L)
Normal	—	36.05 ± 10.52	124.3 ± 16.14	193.0 ± 41.44
10% DMSO + PCM		1714 ± 142.2^#	2266 ± 340.4^#	330.0 ± 42.35^#
NAC + PCM	50	884.2 ± 195.4*	1569 ± 106.4*	284.3 ± 5.536*
MEMC + PCM	50	2734 ± 495.2*	1292 ± 468.0*	311.5 ± 25.64
	250	1638 ± 174.4	2565 ± 170.5	359.0 ± 32.73
	500	244.9 ± 101.9*	526.1 ± 191.1*	221.7 ± 25.55*

Values are expressed as means ± SEM of six replicates.
^#Significantly different as compared to normal group, 𝑃<0.05.
*Significantly different as compared to negative control (10% DMSO + PCM), 𝑃<0.05.