Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window

Figure 6

Local dopamine release from the globus pallidus was monitored by microdialysis. Dialysis probes were implanted in the globus pallidus of EGF-treated, vehicle-treated, and EGF-treated plus risperidone-medicated rats. Dopamine release of EGF-treated rats was elevated in both basal and high potassium (K) evoked conditions. These increases were normalized by subchronic treatment with the antipsychotic risperidone (1 mg/kg/day, 14 days total). ^∗𝑃<0.05 and ^∗∗𝑃<0.01.