Review Article
Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies
Table 1
Nerve injury classification in increasing severity.
| Sunderland [13] | Seddon [29] | Features |
| Type 1 | Neuropraxia | Damage to local myelin only | Type 2 | Axonotmesis | Division of intraneural axons only | Type 3 | Axonotmesis | Division of axons and endoneurium | Type 4 | Axonotmesis | Division of axons, endo- and perineurium | Type 5 | Neurotmesis | Complete division of all elements including epineurium | Type 6* | Mixed | Combination of types 2–4 |
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Mackinnon modification of Sunderland’s criteria [15] and is a common clinical scenario.
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