Liver Autophagy in Anorexia Nervosa and Acute Liver Injury

Figure 3

Role of autophagy in Efavirenz-induced hepatotoxicity. Clinically relevant concentration of Efavirenz induces mitochondrial dysfunction, which in turn induces autophagy, thereby promoting cell survival. However, higher concentration of Efavirenz is associated with inhibition of autophagic flux, which seriously compromises cell survival, ATP: adenosine triphosphate; : mitochondrial membrane potential; ROS: reactive oxygen species.