Characterization of Genipin-Modified Dentin Collagen

Figure 2

Collagen stability of GE-modified dentin collagen. 2 mg aliquots of demineralized dentin treated with PBS (control) and three concentrations of genipin (GE) (0.01%, 0.1%, and 0.5%) for six treatment durations (30 min, 1 h, 4 h, 8 h, 12 h, and 24 h) were subjected to collagenase digestion and hydroxyproline (Hyp) analysis. The mean amounts of undigested collagen with bacterial collagenase are shown as Hyp content (nM) in the insoluble residues. (𝑛=3). ^∗𝑃<0.001, ^∗∗𝑃<0.0001 which are different from the value of control. ^ƚ 𝑃<0.0001 which is different from the value of 0.1% GE. ^a𝑃<0.001, ^b𝑃<0.0001 which are different from the value of 0.5% GE.