Cardiac Electrophysiological Alterations in Heart/Muscle-Specific Manganese-Superoxide Dismutase-Deficient Mice: Prevention by a Dietary Antioxidant Polyphenol
Figure 6
Connexin 43 (Cx43) protein levels in the hearts of control and H/M-Sod2 −/− mice. (a) Cx43 levels in the hearts of control and H/M-Sod2 −/− mice with and without AP intake. Western blot analysis of Cx43 protein extracted from hearts was carried out using antibodies against Cx43 and actin, . (b) Immunostaining with Cx43-specific antibodies of the left ventricular sections of control and H/M-Sod2 −/− mice. Cx43 protein levels in the H/M-Sod2 −/− heart relative to the control heart, and chronic 0.1% AP intake partially improved Cx43 expression. (c) Normalized fluorescence intensity for Cx43 immunostaining of the left ventricular sections obtained from H/M-Sod2 −/− mice. The fluorescence intensity level was normalized to that determined in the left ventricular sections of control mice. Values are mean ± SEM, , *.
