Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease

Table 4

A summary of best 2-, 3-, and 4-locus models of gene-gene interactions obtained by MDR analysis in allergic and nonallergic asthma (exhaustive search algorithm).

Number of loci	Best 𝑛-locus (2-, 3-, and 4-locus) models of gene-gene interactions	Cross-validation consistency, %	Prediction error, %
Allergic asthma (men)
2	CYP2E1 9896C>G × IL5 C-703T	40	52.5
3	CAT −21A>T × IL5 C-703T × GSR T/C*	50	50.3
4	CAT −21A>T × GPX1 P198L × PON2 S311C × IL3 S27P	30	53.6
Allergic asthma (women)
2	EPHX1 Y113H × IL5 C-703T	50	45.8
3	EPHX1 Y113H × IL5 C-703T × GPX1 P198L**	50	40.9
4	EPHX1 Y113H × CYBA 640A>G × GPX4 C718T × PON2 S311C	20	50.1
Nonallergic asthma (men)
2	GPX3 G/A × GCLM −588C>T	30	52.3
3	GCLM −588C>T × GSR T/C × CYBA 242C>T	20	57.0
4	GPX3 G/A × FMO3 E158K × GPX1 P198L × CYBA −930A>G*	30	49.2
Nonallergic asthma (women)
2	EPHX1 Y113H × IL3 S27P	30	46.7
3	EPHX1 Y113H × GSR T/C × SOD2 A16V	60	45.5
4	EPHX1 Y113H × GSR T/C × SOD2 A16V × CYBA 640A>G*	90	27.4

^∗𝐼𝑛𝑑𝑖𝑐𝑎𝑡𝑒𝑠  best 𝑛-locus model of gene-gene interactions evaluated through 1000 permutation tests.
**A statistically significant (𝑃 value 0.001) model of gene-gene interactions.