Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease
Table 6
Associations of genotype combinations with risk of nonallergic asthma (stratified by gender).
Combinations of genotypes
Nonallergic asthma
Controls
Chi-square ( value1)
OR (95% CI)
%
%
Men
GPX1 198PL × CAT −21AA
6
20.7
2
1.9
11.13 (0.001)*
11.45 (2.49–52.66)
GPX1 198LL × GCLM −588CT
4
13.8
3
2.9
3.50 (0.05)
5.17 (1.20–22.31)
GPX3 GA × FMO3 158KK
5
17.2
4
3.8
4.58 (0.03)
5.06 (1.37–18.99)
GPX3 GA × GSR TT
6
20.7
5
4.8
5.68 (0.02)
5.05 (1.49–17.14)
GPX3 GA × CAT −21AA
5
17.2
4
3.8
4.58 (0.03)
5.06 (1.35–18.99)
GPX3 GG × GCLM −588CT
11
37.9
15
14.3
8.12 (0.004)
3.67 (1.47–9.28)
GSR TT × GCLM −588CT
8
27.6
3
2.9
15.31 (0.0001)*
11.58 (3.07–43.72)
GSR TT × FMO3 158KK
4
13.8
1
1.0
7.16 (0.01)
12.29 (1.84–82.03)
CAT −21AA × CYBA −930GG
5
17.2
1
1.0
10.55 (0.001)*
15.64 (2.44–100.3)
CAT −21AA × FMO3 158EE
4
13.8
1
1.0
7.16 (0.01)
12.29 (1.84–82.03)
GCLM −588CT × CYBA −930GG
12
41.4
10
9.5
16.8 (0.00004)*
6.71 (2.5–17.96)
CYBA −930GG × FMO3 158EE
7
24.1
5
4.8
8.22 (0.004)
6.09 (1.85–20.05)
Women
GPX1 198PL × GPX2 GA
2
7.4
0
0.0
3.88 (0.05)
21.47 (1.00–461.1)
GPX2 GG × IL5 −703CT
6
22.2
56
51.4
6.29 (0.01)
0.29 (0.11–0.74)
GPX2 GA × IL5 −703CC
2
7.4
0
0.0
3.88 (0.05)
21.5 (1.00–461.2)
EPHX1 113YH × IL5 −703CT
1
3.7
24
22.0
3.69 (0.05)
0.20 (0.04–1.09)
EPHX1 113HH × IL5 −703CC
7
25.9
4
3.7
11.58 (0.001)*
8.58 (2.43–30.26)
unadjusted value. value adjusted for multiple tests () is less than 0.002 in men and 0.004 in women. *A statistically significant association.
