Abnormal Cardiac Autonomic Regulation in Mice Lacking ASIC3
Figure 1
Baseline cardiovascular activity in the Asic3 −/− mice. (a) Telemetric studies showed both Asic3 +/+ and Asic3 −/− mice with similar baseline HR in resting status (501 ± 5 bpm versus 507 ± 4 bpm). Asic3 −/− mice exhibited lower LF% but normal HF and TP as compared with Asic3 +/+ mice (*, for Asic3 +/+ and for Asic3 −/−). (b) Asic3 −/− mice showed significantly lower systolic, mean, diastolic blood pressure than Asic3 +/+ mice (*). The mean HR of conscious Asic3 −/− mice () was 570 ± 22 bpm and that of Asic3 +/+ mice () was 596 ± 17 bpm.
