Serum Lipids, Apolipoproteins, and Mortality among Coronary Artery Disease Patients
Table 5
Pairwise comparisons of relationships with all-cause and cardiovascular mortality for lipids, apolipoproteins, or their ratiosa.
Hazard ratiosb (95% confidence intervals)
Hazard ratiosc (95% confidence intervals)
All-cause mortality
CVD mortality
All-cause mortality
CVD mortality
Comparisons of single measures
HDL-C
0.91 (0.77–1.07)
0.98 (0.82–1.18)
1.05 (0.85–1.30)
1.17 (0.88–1.42)
Apolipoprotein A-I
0.92 (0.86–0.99)
0.95 (0.88–1.03)
0.91 (0.83–0.99)
0.92 (0.83–1.02)
LDL-C
1.02 (0.98–1.07)
1.06 (1.01–1.12)
1.11 (1.01–1.23)
1.16 (1.04–1.29)
Total cholesterol
1.00 (0.96–1.05)
1.03 (0.98–1.08)
0.92 (0.84–1.01)
0.92 (0.83–1.01)
LDL-C
1.02 (0.98–1.07)
1.06 (1.01–1.12)
1.08 (0.97–1.20)
1.15 (1.02–1.28)
Non-HDL-C
1.01 (0.97–1.06)
1.04 (0.98–1.09)
0.95 (0.86–1.05)
0.92 (0.82–1.03)
Total cholesterol
1.00 (0.96–1.05)
1.03 (0.98–1.08)
0.91 (0.77–1.07)
0.97 (0.81–1.17)
Non-HDL-C
1.01 (0.97–1.06)
1.04 (0.98–1.09)
1.12 (0.94–1.33)
1.07 (0.88–1.29)
LDL-C
1.02 (0.98–1.07)
1.06 (1.01–1.12)
1.03 (0.97–1.09)
1.08 (0.99–1.17)
Apolipoprotein B
1.01 (0.97–1.06)
1.03 (0.98–1.07)
0.99 (0.92–1.07)
0.97 (0.86–1.10)
Apolipoprotein B
1.01 (0.97–1.06)
1.03 (0.98–1.07)
1.02 (0.96–1.07)
1.01 (0.95–1.08)
Total cholesterol
1.00 (0.96–1.05)
1.03 (0.98–1.08)
1.00 (0.95–1.05)
1.02 (0.97–1.09)
Apolipoprotein B
1.01 (0.97–1.06)
1.03 (0.98–1.07)
1.01 (0.95–1.07)
1.01 (0.94–1.08)
Non-HDL-C
1.01 (0.97–1.06)
1.04 (0.98–1.09)
1.01 (0.95–1.06)
1.03 (0.97–1.10)
Comparisons of ratio variables and single measures
LDL/HDL ratio
1.22 (1.06–1.40)
1.27 (1.09–1.49)
1.31 (1.08–1.58)
1.37 (1.10–1.67)
LDL-C
1.02 (0.98–1.07)
1.06 (1.01–1.12)
0.97 (0.91–1.03)
0.98 (0.92–1.05)
LDL/HDL ratio
1.22 (1.06–1.40)
1.27 (1.09–1.49)
1.28 (1.07–1.54)
1.30 (1.07–1.58)
Apolipoprotein B
1.01 (0.97–1.06)
1.03 (0.98–1.07)
0.96 (0.87–1.05)
0.98 (0.89–1.08)
Apolipoprotein B/A-I ratio
1.00 (0.93–1.08)
1.00 (0.92–1.09)
1.00 (0.91–1.09)
0.99 (0.86–1.13)
LDL-C
1.02 (0.98–1.07)
1.06 (1.01–1.12)
1.02 (0.98–1.07)
1.07 (1.01–1.12)
Apolipoprotein B/A-I ratio
1.00 (0.93–1.08)
1.00 (0.92–1.09)
1.00 (0.92–1.08)
0.99 (0.89–1.11)
Apolipoprotein B
1.01 (0.97–1.06)
1.03 (0.98–1.07)
1.01 (0.97–1.06)
1.03 (0.98–1.07)
Comparison of ratio variables
LDL/HDL ratio
1.22 (1.06–1.40)
1.27 (1.09–1.49)
1.22 (1.06–1.42)
1.29 (1.06–1.55)
Apolipoprotein B/A-I ratio
1.00 (0.93–1.08)
1.00 (0.92–1.09)
0.98 (0.81–1.18)
0.94 (0.54–1.66)
Model was adjusted for age, gender, education, marriage, leisure-time physical activity, smoking, alcohol drinking, type, severity, duration, treatment of CAD, history of diabetes, history of heart failure, BMI, systolic blood pressure, glomerular filtration rate, and use of antihypertensive drugs, antidiabetic drugs, antiplatelet drugs, and cholesterol-lowering drugs.
bEvery variable was introduced into the model singly.
cEvery pair of variables was simultaneously introduced into the model.
