Evaluation of Prognostic Significance of Circulating Tumor Cells Detection in Rectal Cancer Patients Treated with Preoperative Radiotherapy: Prospectively Collected Material Data
Table 2
Correlation of circulating tumor cells (CTC) detection in peripheral blood with clinicopathological factors and disease recurrence in patients with a radical resection of primary rectal cancer after preoperative radiotherapy.
Total patients
Preoperative
24 hours after
7 days after
CTC (+)
value
CTC (+)
value
CTC (+)
value
pN0
50
20 (51%)
0.54
3 (27%)
0.049
8 (67%)
0.38
pN1-2
41
19 (49%)
8 (73%)
4 (33%)
pT0–2
29
11 (28%)
0.52
1 (9%)
0.08
5 (42%)
0.43
pT3-4
62
28 (72%)
10 (91%)
7 (58%)
TNM I
23
8 (20%)
0.63
0
0.07
3 (25%)
0.54
TNM II
26
12 (31%)
3 (27%)
5 (42%)
TNM III
41
19 (49%)
8 (73%)
4 (33%)
Cancer recurrence
17
7 (18%)
0.88
2 (18%)
0.88
3 (25%)
0.55
Local recurrence
6
3 (8%)
0.71
1 (9%)
0.72
3 (25%)
0.006
Metastasis
14
6 (15%)
1.00
2 (18%)
0.78
1 (8%)
0.47
Cancer related death
8
4 (10%)
0.67
1 (9%)
0.97
0
0.25
CTC (+): number of patients with circulating tumor cells; pN: lymph nodes metastasis; pT: depth of tumor invasion.