A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis
Figure 2
Aggregate z-scores of THP1r2Mtb-iNet[] and box-plotting. Sets of integrated THP1r2Mtb-iNet[] were extracted with involvement of different sets of hubs with minimum degree . The adjusted values of genes in THP1r2Mtb-iNet[] at 18 h after infection relative to 4 h after infection were converted into -scores. The aggregate -scores of THP1r2Mtb-iNet[] as a whole were then calculated, which enabled comparison among signatures with different sizes [13]. The sizes of the relevant signatures based on hubs with minimum degree 14 were also enumerated (a). Then the signature with the highest aggregate -score (TMtb-iNet), the cognate excluded signature (TMtb-iEx), and the parent signature (THP1r2Mtb-induced) were box-plotted for mutual comparison of their expressions (b).
