A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis

Table 1

GSEA using transcriptome data of whole blood from human PTB patients.

Cohort^1	Group comparison^2	THP1r2Mtb-induced			TMtb-iNet			TMtb-iEx
		NES^3	FDR^4	Correlation^4	NES^3	FDR^4	Correlation^4	NES^3	FDR^4	Correlation^4
Training set	PTB versus HC	3.23	0.000	Positive	3.30	0.000	Positive	2.66	0.000	Positive
	PTB versus LTB	3.00	0.000	Positive	3.01	0.000	Positive	2.53	0.000	Positive
	LTB versus HC	−1.22	0.071	Null	−0.91	0.902	Null	−1.37	0.062	Null
Test set	PTB versus HC	3.46	0.000	Positive	3.48	0.000	Positive	2.86	0.000	Positive
	PTB versus LTB	3.12	0.000	Positive	3.23	0.000	Positive	2.51	0.000	Positive
	LTB versus HC	2.37	0.000	Positive	2.25	0.000	Positive	2.11	0.000	Positive
Validation set	PTB versus LTB	3.27	0.000	Positive	3.28	0.000	Positive	2.59	0.000	Positive

¹Training set and test set: all donors were from London, UK; PTB: pulmonary TB; LTB: latent TB; HC: healthy controls; validation set: all donors were from Cape Town, South Africa [2].
²Group-group contrasted and ranked by LIMMA-based method [27, 28].
³(+) NES for positive correlation, (−) NES for negative correlation.
⁴A FDR of 0.05 or lower was regarded as statistically significant for NES (“positive” or “negative”), otherwise “Null.”