The Wedelolactone Derivative Inhibits Estrogen Receptor-Mediated Breast, Endometrial, and Ovarian Cancer Cells Growth
Figure 2
Differential growth inhibition effects of BTB on ERα-positive versus ERα-negative breast, endometrial, and ovary cancer cell lines. Cells were treated with 2.5 μM BTB or mock EtOH in the absence or presence of 10 nM E2. Phenol red free DMEM medium with indicated treatment was refreshed every 2 days for a total of 6 days. (a)–(c) BTB Inhibits the E2-induced growth of ER-positive breast cancer MCF-7, endometrial cancer Ishikawa, and ovarian cancer SKOV-3 cells. (d)–(f) BTB has no effect on the growth of ER-negative breast cancer MDA-MB-231, endometrial cancer HEC-1-A, and ovarian cancer OVCA429 cells. Data represent mean ± SD collected from three independent experiments.
