Research Article

Silencing of Plasma Membrane Ca2+-ATPase Isoforms 2 and 3 Impairs Energy Metabolism in Differentiating PC12 Cells

Figure 5

Glucose consumption and lactate release. (a) Changes in glucose concentration assessed in culture medium (+glucose) or in medium supplemented with metabolic inhibitors: 2-deoxyglucose or oligomycin. (b) Accompanied changes in lactate release determined under the same conditions. In both panels, versus nontreated cells; versus control cells. : mock-transfected PC12, _2: PMCA2-reduced PC12, and _3: PMCA3-reduced PC12.
735106.fig.005a
(a)
735106.fig.005b
(b)