Epigenetic Alterations of Chromosome 3 Revealed by NotI-Microarrays in Clear Cell Renal Cell Carcinoma
Table 3
Frequency of alterations and relative mRNA level of 8 genes in ccRCC and pRCC.
Genes
Frequency of mRNA level changes, %
Median of mRNA level changes, -fold*
ccRCC
pRCC
ccRCC
pRCC
↓
↑
↓
↑
LRRN1
53 (9/17)
0 (0/17)
11 (1/9)
33 (3/9)
3↓(1–15↓)
3↑(2.1 × 103↑–10↓)
GORASP1
42 (5/12)
0 (0/12)
36 (4/11)
0 (0/12)
1 (1–3↓)
1 (1–7↓)
IQSEC1
0 (0/12)
8 (1/12)
58 (7/12)
0 (0/12)
1 (3↑–1)
2↓ (1–53↓)
FOXP1
20 (2/10)
0 (0/10)
17 (2/12)
25 (3/12)
1 (1–2↓)
1 (19↑–14↓)
GNAI2
8 (1/12)
33 (4/12)
17 (2/12)
25 (3/12)
1 (4↑–2↓)
1 (3↑–4↓)
FGD5
25 (3/12)
8 (1/12)
83 (10/12)
0 (0/12)
1 (3↑–7↓)
3↓(1–59↓)
PLCL2
50 (6/12)
0 (0/12)
83 (10/12)
8 (1/12)
1 (1–5↓)
3↓(2↑–8↓)
ALDH1L1
92 (11/12)
0 (0/12)
92 (11/12)
0 (0/12)
4↓(1–1.1 × 102↓)
6↓(1–1.6 × 102↓)
Note: qPCR data. ↓/↑: mRNA level decrease/increase. *In parentheses a range of relative mRNA level is shown. The highest frequencies of mRNA level changes are shown in bold (P < 0.05 for all cases).
