Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Figure 1

Schematic illustration of routes of migration of mouse DCs. DC precursors are released from the BM into the blood; DC progenitors can also be found in multiple locations including the thymus, blood, lymph, and most visceral organs. DC precursors seeded peripheral lymphoid tissues and nonlymphoid tissues and differentiated them into committed DCs. cDCs in peripheral tissues can access afferent lymph upon receiving a mobilization signal and travel to the draining LNs during both inflammation and steady-stated. pDCs travel to the LNs and spleen via hematogenous route. Some DCs might exit lymph nodes (LN) and start a still undefined pathway to recirculate. The circulating DCs in the blood contain both DC precursors and differentiated DC subsets, which are a mixture of newly generated cells from the BM and experienced DCs which have reentered the circulation from peripheral tissues.