Receptor Ligands Cellular distribution Role in migration Reference
CCR1
MIP-1
/CCL9
Immature DCs Recruitment of CD11b+ DCs to the dome regions of Peyer’s patch [22 ] Recruitment of DC precursors into airway epithelium during bacterial inflammation and steady-state [23 ]
CCR2
CCL2/MCP-1
Immature DCs Recruitment of DCs in the lung during allergic inflammation, and supposed to be critical in inducing T(H)2 responses [24 , 25 ] Recruitment of CD11cdim/intermediate DCs in the lung during mycobacterium tuberculosis infection and cDCs during Cryptococcus neoformans infection, may be important in inducing T(H)1 responses [26 , 27 ] Mature DCs Activated LC migrate from skin to draining LNs and regulate infection-induced relocalization of CD11c+ DC in spleen [28 ] CCR5 MIP-1
/CCL3 MIP-1
/CCL4 Rantes/CCL5 Immature DCs mature DCs Recruitment of pDC to inflamed peripheral lymph nodes [29 ] CCR6 CCL20/MIP-3
Immature myeloid DC, subsets of pDCs Recruitment of myeloid CD11c+ CD11b+ dendritic cells to the dome regions of Peyer's patches [30 , 31 ] Recruitment of myeloid DCs to the inflamed epithelial tissues such as skin [32 ] mediate pDC recruitment to inflamed epithelia [33 ]
CCR7
CCL19/MIP-3
CCL21/SLC
Mature DCs essential for directing the antigen-loaded mature cDCs to the T cell-rich areas of the draining lymph node during inflammatory and steady-state conditions [34 ] Migration of pDCs to LNs via HEV under both steady-state and inflammatory conditions [35 ] Migration of pDC to the splenic white pulp under steady-state conditions [36 ] CCR9 CCL25 Myeloid and pDC Controls the migration of pDC to the small intestine under both steady-state and inflammatory conditions [37 ] CCR10 CCL27 CCL28 Subset of tonsil pDCs, IL-3-cultured blood pDCs Mediate pDC homing into inflamed epithelia [33 ] CXCR3 CXCL9 CXCL10/IP-10 CXCL11 pDC precursors pDC CD11c+ myeloid DCs monocyte-derived iDC Migration of pDC to inflamed LNs via HEV [38 ] migration and clustering of splenic plasmacytoid DCs in the spleen marginal zone [39 ] CXCR4 CXCL12/SDF-1
Immature DCs mature DCs pDC Migration of skin dendritic cells to LNs [40 ] Migration of pDC to the splenic white pulp under steady-state conditions [36 ] CXCR5 CXCL13/BLC/BCA-1 Activated skin DC Activated dermal DC migrate to draining LNs [41 ]