Review Article
Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration
Table 2
Chemokine receptors and chemokines involved in migration of human DCs subsets.
| Receptor | Ligands | Cellular distribution | Role in migration | Reference |
| CCR1 | MIP-1/CCL9 | Immature DCs | May be involved in human peripheral blood monocyte-derived dendritic cells migration | [42] |
| CCR2 | CCL2/MCP-1 | Immature mature DCs | Recruitment of circulating blood DCs and monocytes to inflamed tissue | [43] |
| CCR3 | Eotaxin eotaxin-2 | Immature DCs mature DCs | May be involved in dendritic cells migration | [42, 44] |
|
CCR5 |
MIP-1/CCL3 MIP-1/CCL4 Rantes/CCL5 |
Immature DCs mature DCs | Attract DCs to migrate cross the human intestinal epithelium and sample luminal virions | [45] | May contribute to the recruitment of blood myeloid DC to cerebrospinal fluid in multiple sclerosis patients and acute optic neuritis. | [46] | May be involved in the altered homing of blood DCs during the alloimmune response | [47] |
|
CCR6 |
CCL20/MIP-3 |
pDCs | May be involved in leukemic pDCs and blood pDCs from melanoma patients recruitment to lesions of skin | [48, 49] | Recruitment of circulating blood DCs and monocytes to inflamed tissue | [43] |
| CXCR3 | CXCL9 CXCL10/IP-10 CXCL11 | pDCs immature CD1a+ DC | Might be involved in the recruitment of pDC and immature CD1a+ DCs to tissue lesions | [50, 51] |
| ChemR23 | Chemerin | Immature pDCs | Migration plasmacytoid dendritic cells to lymphoid organs and inflamed skin | [52, 53] |
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