Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Table 2

Chemokine receptors and chemokines involved in migration of human DCs subsets.

Receptor	Ligands	Cellular distribution	Role in migration	Reference
CCR1	MIP-1𝛾/CCL9	Immature DCs	May be involved in human peripheral blood monocyte-derived dendritic cells migration	[42]
CCR2	CCL2/MCP-1	Immature; mature DCs	Recruitment of circulating blood DCs and monocytes to inflamed tissue	[43]
CCR3	Eotaxin; eotaxin-2	Immature DCs; mature DCs	May be involved in dendritic cells migration	[42, 44]
CCR5	MIP-1𝛼/CCL3; MIP-1𝛽/CCL4; Rantes/CCL5	Immature DCs; mature DCs	Attract DCs to migrate cross the human intestinal epithelium and sample luminal virions	[45]
			May contribute to the recruitment of blood myeloid DC to cerebrospinal fluid in multiple sclerosis patients and acute optic neuritis.	[46]
			May be involved in the altered homing of blood DCs during the alloimmune response	[47]
CCR6	CCL20/MIP-3𝛼	pDCs	May be involved in leukemic pDCs and blood pDCs from melanoma patients recruitment to lesions of skin	[48, 49]
			Recruitment of circulating blood DCs and monocytes to inflamed tissue	[43]
CXCR3	CXCL9; CXCL10/IP-10; CXCL11	pDCs; immature CD1a^+ DC	Might be involved in the recruitment of pDC and immature CD1a^+ DCs to tissue lesions	[50, 51]
ChemR23	Chemerin	Immature pDCs	Migration plasmacytoid dendritic cells to lymphoid organs and inflamed skin	[52, 53]