Mannose-Binding Lectin Codon 54 Gene Polymorphism and Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis

Table 1

Characteristics of case-control studies which are included in meta-analysis.

First author, year; of publication	Country	Ethnicity	Participant origin	Average age^a of		Sample size; (cases/controls)	No. of genotypes; (cases/controls)
				Cases	Controls		AA	AB	BB
Studies describing association between MBL codon 54 gene polymorphism and RVVC
Babula, 2003 [14]	Latvia	Latvian	Hospital outpatient service	27 (18–35)	25 (18–35)	42/43	13/39	26/4	3/0
Liu, 2006 [17]	China	Chinese	Hospital outpatient service	29 ± 6	31 ± 5	6/54^b	1/43	5/8	0
Giraldo, 2007 [16]	Brazil	White/nonwhite	Hospital outpatient service	31 (18–68)^c	33 (16–70)	50/66	31/53	13/12	6/1
Donders, 2008 [18]	Belgium	Caucasian, Asian	Hospital outpatient service	36 ± 9	33 ± 10	109/55	69/48	36/7	4/0
Wojitani, 2012 [15]	Brazil	White/nonwhite	Hospital outpatient service	32 (18–50)	30 (19–49)	100/100	58/84	30/15	12/1
Studies describing association between MBL codon 54 gene polymorphism and VVC
Liu, 2006 [17]	China	Chinese	Hospital outpatient service	33 ± 8	31 ± 5	51/54^c	34/43	17/8	0
Giraldo, 2007 [16]	Brazil	White/nonwhite	Hospital outpatient service	31 (18–68)^c	33 (16–70)	28/66	18/53	10/12	0/1

MBL: mannose-lectin binding; RVVC: recurrent vulvovaginal candidiasis; VVC: vulvovaginal candidiasis.
^aExpressed as median with range or mean ± standard deviation, as reported in the original paper.
^bFor three of 51 patients, genotypes were not determined because DNA could not be extracted from the respective samples.
^cCalculated on the overall group of (R)VVC cases, as reported in the original paper.