Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole
Table 2
Effect of adrenaline alone and after dosing of compounds 1, 16, 19, 20, 23, 24, 27, and 28 on systolic (SABP) and diastolic (DABP) arterial blood pressure and heart rate (HR) of anaesthetized albino rats.
Comp. number
Parameter
Effect of adrenaline alone
Effect of adrenaline after 1/2 h. from inj. test comp.
Effect of adrenaline after 1 h from inj. test comp.
Effect of adrenaline after 2 h from inj. test comp.
control
effect
% change
30 min.
effect
% change
60 min.
effect
% change
120 min.
effect
% change
1
SABP
+28.8
+6.5
+3.3
0
DABP
+16.6
+9.6
−2
0
HR
+21
0
0
0
16
SABP
+19.6
−7.6
−2.1
0
DABP
+15.7
−7.6
−3.4
0
HR
+24
+1.9
0
0
19
SABP
+19.8
−9
−5.2
−3.4
DABP
+25
−8.2
−6.2
0
HR
+31
0
0
0
20
SABP
+25.3
−10
−4
0
DABP
+20.9
−6.6
−2.2
0
HR
+25
0
0
0
23
SABP
+27.3
−9.8
−14
−10
DABP
+18.9
−13
−8.5
−5.5
HR
+18.8
0
0
0
24
SABP
+28.3
−11.6
−20
−13.8
DABP
+22.4
−12.6
−10.7
−14.2
HR
+13.5
0
0
0
27
SABP
+22.9
−7.6
−2.3
0
DABP
+30.6
−10.8
−2.2
0
HR
+23
0
0
0
28
SABP
+24.3
−6.2
−1.7
0
DABP
+20.6
−8.8
−2
−2
HR
+23
0
0
0
PZN
SABP
+16.8
−10.7
−2.4
−1.2
DABP
+18.6
−7.6
−1.6
0
HR
+20.7
+4
−2.4
−4.5
All values were expressed as Mean S.D.; each group comprised 6 animals (i.e., ), prazosin (PZN). Significantly different from respective control value at . N.s. = nonsignificantly different from respective control value at . % change = BP initial−BP after drug adm./BP initial .
