Store-Operated Ca2+ Entry Does Not Control Proliferation in Primary Cultures of Human Metastatic Renal Cellular Carcinoma
Figure 1
Phenotypic characterization of primary cultures of mRCC cells. (a) Morphology of mRCC cells (hematoxylin and eosin). (A) The cultured proliferation is composed of loose sheets of neoplastic cells on a scant background composed of histiocytic elements (HE, 10x); (B) at higher magnification (HE, 40x), prominent cytologic atypia is evident, consistent with pleomorphism, irregular nuclei with altered nuclear-to-cytoplasm ratio, nuclear pycnosis (black arrows), and mitoses (white arrows). (b) Expression of anti-CD10 mAb on the surface of mRCC cells as compared to the control isotype.
