Store-Operated Ca²⁺ Entry Does Not Control Proliferation in Primary Cultures of Human Metastatic Renal Cellular Carcinoma

Figure 5

Lanthanides inhibit store-operated Ca²⁺ entry in mRCC cells. Forty minutes pretreatment with Gd³⁺ (10 μM) selectively inhibited SOCE elicited by either CPA (10 μM; (a)) or thapsigargin (2 μM; (c)). Statistical evaluation conducted on more than 100 cells per condition confirmed that Gd³⁺ reduced SOCE, but not intracellular Ca²⁺ release, activated by CPA (b) or thapsigargin (d). ^∗𝑃<0.05 (Student’s 𝑡 test).

(a)

(b)

(c)

(d)