Ibuprofen Protects Ventilator-Induced Lung Injury by Downregulating Rho-Kinase Activity in Rats

<table>Representative electron micrographs of the control, HVZP, HVZP + ibuprofen (Ibu) 15 mg/kg, and HVZP + ibuprofen 30 mg/kg groups. The capillary profile was normal and is lined by continuous endothelium (black arrow). The HVZP group showed discontinuous endothelial cell lining (white arrow) and large endothelial cell membrane vacuolization (<svg height="7.9250002" id="M22" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 7.9250002" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,7.863)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5
q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g>
</svg>) protruding into the capillary lumen. The ultrastructure of the HVZP + Ibu 15 mg/kg and HVZP + Ibu 30 mg/kg groups revealed normal endothelial continuity as the control group. EC: erythrocyte, EN: endothelium, and A: alveolar space.</table>

BioMed Research International

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Figure 7

Figure 7: Ibuprofen Protects Ventilator-Induced Lung Injury by Downregulating Rho-Kinase Activity in Rats 