Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a

Table 1

The intermolecular interactions shared between NS3 of HCV genotypes 1 and 3.

Residue	Interactions shared among model and templates; (bonding atom of residue)
Ala204	HB NZ of Lys210
Lys210	HB O of Ala204
	HB O of Pro205
Ser231	HB OG1 of Thr235
	HB O of Thr416
Thr266	Hb OH of Tyr284
Tyr267	HB O of Ser211
Ile288	HYD CB of Val319
Asp290	HB OG of Ser211
	HB OH of Tyr270
His293	HB OG1 of Thr322
His369	HB OH of Tyr350
Tyr392	HB OD2 of Asp375
Phe438	HYD CB of Phe444
	HYD CE2 of Phe531
	HYD CE of Met623
	HYD CZ2 of Trp532
	HYD CD1 of Leu627
Phe444	HYD CZ3 of Trp532
	HYD CD1 of Leu560
	HYD CG2 of Ile619
	HYD CE of MET623
Gln460	HB NE of Arg464
Arg461	HB OD1 of Asp410
	HB OD1 of Asp425
Arg462	HB O of Val331
	HB OE2 of Glu338
Gly463	HB NH1 of Arg467
Arg464	HB O of Tyr418
	HB O of Gly420
Thr465	HB O of Phe422
	HB O of Asp423
	HB OG1 of Thr465
Gly466	HB ND2 of Asn335
Arg467	HB O of Thr419

HB = hydrogen bond, Hb = hydrogen bond, CB = carbon atom with number, O = oxygen in hydroxyl group, OG = oxygen of amino acid with some number, that is, G, OG1 = oxygen with number, that is, G1, OH = oxygen with distinct number, that is, H, CE = carbon atom of amino acid with some number, that is, E, CE2 = carbon atom with some number, that is, E2, CD1 = carbon atom with some distinct number, that is, D1, NE = nitrogen atom with number, that is, E, NH1 = nitrogen atom with some number, that is, H1, HYD = hydrophobic bond.