Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a

Table 2

List of nonconserved residues in HCV NS3 genotype 3a structure in comparison with other HCV NS3 genotypes. Bold residues were seen shared among templates and models.

Position of the residue	Crystal structures		Model of NS3 GT3a
	Residue	Interactions	Residue	Interactions
219	ALA	—	VAL	VAL225, ILE248, LEU265
224	LYS	ALA283, ASP285	ASN	ASP285
286	ILE	LEU317, VAL319	VAL	LEU317, VAL319
297	SER	GLU493	ALA	—
315	ALA	—	VAL	ILE285
354	ILE	ILE359, ILE366, ILE426	LEU	LEU341, ILE426, PHE349, LEU358
358	THR	—	LEU	LEU358
377	LEU	LEU381, VAL409	ILE	LEU381
384	LEU	—	MET	ILE345
407	ILE	—	VAL	ILE357, ILE364, LEU379
430	THR	ARG461	VAL	ARG461
433	THR	—	GLU	ARG479
445	THR	—	SER	SER439
477	THR	—	SER	ASN429, ARG458
489	SER	—	VAL	PHE557, VAL436, ILE446
500	ALA	LYS551	SER	ASP496
505	THR	—	GLN	THR509
510	SER	GLU533	THR	—
530	GLU	—	ASP	SER534
553	ALA	—	GLN	LYS583
561	VAL	MET581, TRP582, LEU602	THR	PHE557
605	VAL	VAL609	ILE	VAL609, LEU598