Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways

<table>Indirect p53 regulation with miRNAs. p53 controls its stability and activity with the p53-inducible miRNAs that directly or indirectly target the negative regulators (MDM2 and SIRT1).<i> miR-25</i>,<i> miR-32</i>,<i> miR-18b</i>, and<i> miR-449</i> are not direct targets of p53 but repress the negative regulators and lead to p53 activation.</table>

BioMed Research International

fig2

Figure 2

Figure 2: Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways 