Effect of Duplicate Genes on Mouse Genetic Robustness: An Update
Figure 3
The effect of sequence conservation on the relationship between and duplication age. (a) Relationship between in duplicate genes (blue) or singletons (purple) and the evolutionary conservation of the gene, measured by the ratio of the nonsynonymous () to synonymous () nucleotide distances between the target gene and its human ortholog. Linear regression line and regression equation between ratio and in knockout single-copy genes are presented on the panel. (b) Mean ratio for each age bin of duplicates. Dashed line denotes the mean ratio of singleton mouse knockout genes. (c) in each age bin of duplicates— (dup, t)—and that of singletons with the same ratio—. is calculated based on the mean ratio for duplicates in each age bin (panel b) and the linear regression equation (panel a). (d) Ratio of (dup, t) and in each age bin of duplicates. Error bars show one standard error.
