Molecular Imaging in Stem Cell Therapy for Spinal Cord Injury

Table 1

Stem cell-based cell therapy in experimental SCI models.

Cell type	Cell number	Route	Time after SCI	Weeks after cell injection	Host animal	Cotreatment method	Functional outcome	References
BMSCs	5 × 10^6	IL	24 h	3	Rabbit	BMSCs were Ngb gene-modified	Significant functional improvement	[16]
OPCs	5 × 10^5	IL	3 d	4	Rat	No	Functional improvements in SSEP amplitudes and latencies	[17]
iPSC-NS/PCs	1 × 10^6	IL	9 d	12	Marmoset	No	Promoted functional recovery	[18]
NSCs + OECs	3 × 10^5	IL	Immediately	4	Rat	Cotransplantation of NSCs and OECs	Improve sensory function	[19]
ESCs	5 × 10^5	IV	2 h	4	Mice	No	Promoted hind-limb recovery	[20]
iPSCs	5 × 10^5	IL	9 d	6	Mice	No	Promoting locomotor function recovery	[21]
NS/PCs	8 × 10^4	IL	9 d	8	Rat	Coinjected with HAMC	Enhanced tissue benefit and functional recovery	[22]
EMSCs	5 × 10^4	IL	0.5 h	12	Rat	Coinjected with fibrin scaffolds	Improve the behavioral; and histological recovery	[23]
BMSCs	1 × 10^7	IL	7 d	4	Dog	No	Improved functional recovery	[24]

IL: intralesional injection, IT: intratheca injection, IV: intravenous injection, BMSCs: bone marrow mesenchymal stem cells, Ngb: neuroglobin, SSEPs: somatosensory evoked potential, iPSC-NS/PCs: induced pluripotent stem cell-derived neural stem/progenitor cells, HUCBCs: human umbilical cord blood cells, hES: transplanted human embryonic stem, OPCs: cell-derived oligodendrocyte progenitor cells, ESCs: embryonic stem cells, iPSCs: induced pluripotent stem cells, NSPCs: neural stem/progenitor cells, HAMC: hydrogel blend of hyaluronan and methyl cellulose, and EMSCs: ectomesenchymal stem cells.