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BioMed Research International
Volume 2014 (2014), Article ID 761312, 9 pages
http://dx.doi.org/10.1155/2014/761312
Review Article

Magnetic Resonance-Guided Laser Induced Thermal Therapy for Glioblastoma Multiforme: A Review

1Biomedical Engineering Department, University of Tennessee, Knoxville, TN 37996, USA
2University of Tennessee Space Institute, Tullahoma, TN 37388, USA

Received 13 April 2013; Revised 21 October 2013; Accepted 21 October 2013; Published 16 January 2014

Academic Editor: Beric Henderson

Copyright © 2014 Sarah E. Norred and Jacqueline Anne Johnson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Magnetic resonance-guided laser induced thermotherapy (MRgLITT) has become an increasingly relevant therapy for tumor ablation due to its minimally invasive approach and broad applicability across many tissue types. The current state of the art applies laser irradiation via cooled optical fiber applicators in order to generate ablative heat and necrosis in tumor tissue. Magnetic resonance temperature imaging (MRTI) is used concurrently with this therapy to plan treatments and visualize tumor necrosis. Though application in neurosurgery remains in its infancy, MRgLITT has been found to be a promising therapy for many types of brain tumors. This review examines the current use of MRgLITT with regard to the special clinical challenge of glioblastoma multiforme and examines the potential applications of next-generation nanotherapy specific to the treatment of glioblastoma.