A Novel Approach for Discovering Condition-Specific Correlations of Gene Expressions within Biological Pathways by Using Cloud Computing Technology

Table 3

Pathways containing different correlated genes between relapse and nonrelapse breast cancer patients.

ID	Pathway names	Differential correlation genes (cor_Dif*)
hsa05200	Pathways in cancer	NFKB2 → PTGS2 (+0.37)
		JUN → MMP1 (+0.29)
		RUNX1→ CEBPA (+0.29)
		JUN → FIGF (−0.27)
hsa04151	PI3K-Akt signaling pathway	FGF4 → EGFR (−0.32)
		IRS1 → PIK3CB (−0.3)
		CSF1 → KIT (+0.3)
		EFNA1 → IGF1R (−0.28)
hsa04722	Neurotrophin signaling pathway	IRS1 → PIK3CG (+0.34)
		RPS6KA2 → NRAS (+0.3)
		IRS1 → PIK3CB (−0.3)
hsa04062	Chemokine signaling pathway	GNB5 → PIK3R5 (+0.31)
		CCL18 → XCR1 (−0.29)
hsa04150,	mTOR signaling pathway
hsa04910,	Insulin signaling pathway	IRS1 → PIK3CG (+0.34)
hsa04930,	Type II diabetes mellitus	IRS1 → PIK3CB (−0.3)
hsa04960	Aldosterone-regulated sodium reabsorption
hsa04010	MAPK signaling pathway	DUSP2 → MAPK8 (−0.34)
hsa04060	Cytokine-cytokine receptor interaction	IL17A → IL17RA (−0.32)
hsa04310	Wnt signaling pathway	SFRP5 → WNT11 (+0.3)
hsa04520	Adherens junction	WAS → ACTB (−0.39)
hsa04530	Tight junction	PRKCQ → ACTB (−0.34)
hsa04612	Antigen processing and presentation	HLA-E → KIR2DS1 (−0.29)
hsa04620	Toll-like receptor signaling pathway	RIPK1 → TRAF6 (+0.31)
hsa04630	Jak-STAT signaling pathway	STAT6 → SOCS1 (+0.31)
hsa04666	Fc gamma R-mediated phagocytosis	WASF3 → ARPC2 (+0.3)
hsa04725	Cholinergic synapse	GNB5 → PIK3R5 (+0.31)
hsa05012	Parkinson's disease	SLC25A4 → CYCS (+0.28)
hsa05020	Prion diseases	PRNP → BAX (+0.29)
hsa05152	Tuberculosis	MAPK3 → IL23A (+0.31)
hsa05211	Renal cell carcinoma	EGLN3 → EPAS1 (+0.28)

∗cor_Dif: average correlation of genes in nonrelapse samples − average correlation of genes in relapse samples.