Novel RNA Markers in Prostate Cancer: Functional Considerations and Clinical Translation

Table 3

MiRNA-based therapeutics in prostate cancer preclinical trials.

miRNA	Target	Model used	Delivery method	Phenotypes	Reference
Let-7	Myc, RAS	AR-negative mouse xenograft	Let-7c-lentivirus intratumoral injection	Repressed tumor growth	Nadiminty et al. [102]
miR-199a-3p	Aurora kinase A	DU145 mouse xenograft	Agomir intratumoral injection	Reduced tumor growth	Qu et al. [104]
miR-16	CDK1, CDK2	Murine bone metastatic prostate cancer model	Intravenous injections	Reduced tumor development in bone tissue	Takeshita et al. [105]
miR-34a	CD44, SIRT1	CD44^+ mouse xenograft	Intratumoral and systemic injection of miR-34a oligo	Reduced tumor volume and lung metastasis, prolonged survival	Liu et al. [107]
miR-221	p27	PC-3 mouse xenograft	Intratumoral injections of miR-221/miR-222 antagomirs	Reduced tumor growth	Mercatelli et al. [110]