Cardiac Phosphoproteomics during Remote Ischemic Preconditioning: A Role for the Sarcomeric Z-Disk Proteins
Table 1
RIPC-induced changes in phosphoproteins measured using TMT. Data shown are for Series 1 (3 control and 3 RIPC). Fold change was calculated by taking average values for control and for RIPC.
Phospho-proteins
Protein accession
Fold change
value
value normalized to p-GAPDH
Myozenin-2
Q9JJW5
1.7
0.021*
0.043*
PDZ and LIM domain protein 5
E9Q8P5
1.3
0.003*
0.057
Protein Pkp2
E0CX59
1.3
0.008*
0.012*
Protein Tns1
E9Q0S6
1.3
0.006*
0.035*
Apoptosis-inducing factor short isoform 2
Q1L6K5
1.2
0.033*
0.040*
Isoform 2 of AP2-associated protein kinase 1
Q3UHJ0-2
1.4
0.014*
0.013*
Isoform 3 of synaptopodin
Q8CC35-3
1.3
0.036*
0.094
Ryanodine receptor 2
E9Q401
1.2
0.043*
0.196
Obscurin
F7DCJ0
1.2
0.012*
0.32
Alpha-T-catenin isoform X
A4GE65
1.2
0.033*
0.159
Ubiquitin carboxyl-terminal hydrolase
B1AY13
1.2
0.029*
0.031*
Sorbin and SH3 domain-containing protein 2
B2RXQ9
1.4
0.007*
0.050
ENH isoform 1e
D9J302
1.2
0.003**
0.051
p53-induced protein with a death domain
Q9ERV7
1.3
0.034*
0.092
Calnexin
P35564
1.2
0.071
0.013*
-value calculated using unpaired -test ( considered as significant). values between 0.05–0.1 indicate strong trend.
