Knockdown of AKT3 (PKBγ) and PI3KCA Suppresses Cell Viability and Proliferation and Induces the Apoptosis of Glioblastoma Multiforme T98G Cells

Figure 2

Effect of siRNA on T98G cells. ((a), (b)) Comparison of mRNA copy numbers for AKT3 (a) and PI3KCA (b) between transfected and untransfected T98G cells (AKT3: 𝑃<0.01, 𝑡=4.178, 𝛽=0.981; PI3KCA: 𝑃<0.01, 𝑡=4.98, 𝛽=0.987); ((c), (d)) dot-plots for comparison of the percentage of AKT3 protein-positive cells after AKT3 and PI3KCA knockdown and without using AKT3 siRNA; analysis was performed using flow cytometry; ((e), (f)) comparison of the percentage of AKT3 or PI3KCA protein-positive cells between the groups that were analyzed (𝑃<0.05).

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