Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

Table 1

Long noncoding RNA expressed in the HCC.

LncRNA ID	Dysregulation	Upstream; regulators	Downstream; targets	Cellular; functions	Clinicopathological; features
lncRNA-Dreh	Downregulated	HBx protein	Vimentin	Cytoskeleton structure	Prognosis
lncRNA HEIH	Upregulated		EZH2	Cell cycle	Prognosis
			PRC2
lncRNAMVIH	Upregulated		PGK1	Microvessel growth	Metastasis
					Prognosis
HULC	Upregulated	CREB	miR-372	Proliferation	Metastasis
		HBx	p18
HOTAIR	Upregulated	Suz-Twelve	PRC2	Chrome state	Metastasis
			LSD1		Prognosis
MDIG	Upregulated	c-Myc and RB	H3K9me3	DNA repair	Prognosis
			IGF2
			macrosatellite X56
			Jhdm3a
MALAT1	Upregulated	TGF-beta	Caspase-3	Proliferation	Metastasis
			Caspase-8	Apoptosis	Prognosis
			BAX	Migration
			BCL-2	Invasion
			BCL-XL	Synaptogenesis
			PRC1
MEG3	Downregulated	cAMP	p53	Proliferation	Prognosis
			MDM2
			GDF15