Global Analysis of miRNA Gene Clusters and Gene Families Reveals Dynamic and Coordinated Expression
Figure 1
Examples of deregulation patterns of miRNA gene clusters and families (a) and their dynamic expression patterns (b). (a) Members in these miRNA gene clusters and families may be repeated. Some clusters are members of a specific gene family. The horizontal axis indicates the miRNA gene cluster or gene family; and the vertical axis indicates the fold change value (log2) based on each pair of tumor and adjacent normal samples. Bars in different colors (blue, red, green, and purple) indicate fold change value (log2) of the four pairs of tumor and adjacent normal samples, respectively; (b) dynamic expression across the 8 involved samples (P1-tumor, P1-normal, P5-tumor, P5-normal, P6-tumor, P6-normal, P7-tumor, and P7-normal). The horizontal axis indicates the 8 samples, and the vertical axis indicates the relative expression (percentage).
