A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis

Table 3

Summary of the included amyloid-PET studies included with LHR and GRADE analysis.

Authors	Population	Method	Cohort investigated	Follow-up months	Sens.	Spec.	LHR+	Increase in the LHR+	Quality of evidence (GRADE)
Barthel et al., 2011 [96, 97]	81 AD; 69 HC	ROI SUVR analysis	81	—	0.85	0.91	9.44	Moderate	M
Rabinovici et al., 2011 [34]	62 AD; 45 FTD	ROI DVR analysis	107	12	0.89	0.83	5.24	Moderate	M
Rostomian et al., 2011 [58]	42 AD; 31 FTD	ROI DVR analysis	73	16	0.905	0.84	5.66	Moderate	M
Rowe et al., 2008 [93]	15 AD; 5 FTD; 15 HC	SUVR analysis	20	12	1	0.9	10.00	Moderate	L
Villemagne et al., 2011 [12]	30 AD; 20 MCI; 32 HC; 11 FTD; 7 LBD; 5 PD; 4 VaD	SUVR analysis	30	—	0.97	0.84	6.06	Moderate	M
Clark et al., 2012 [102]	5 MCI; 29 AD; 12 HC; 13 ODD	SUVR analysis	47	24	0.97	0.99	97.00	Large	M
Camus et al., 2012 [29]	13 AD; 12 MCI; 21 HC	SUVR + Visual	13	—	0.923	0.905	9.72	Moderate	VL
Koivunen et al., 2011 [62]	29 MCI; 13 HC	PiB retention analysis	29	24	0.94	0.42	1.62	Minimal	VL
Mosconi et al., 2009 [19]	31 MCI	ROI ratio SPM	31	32.16	0.93	0.76	3.88	Small	L
Forsberg et al., 2010 [100]	37 mild AD; 21 MCI	ROI ratio SPM	58	33	1	0.71	3.45	Small	L
Jack et al., 2010 [46]	53 MCI	DVR	53	20.4	0.83	0.46	1.54	Minimal	VL
Wolk et al., 2009 [101]	23 MCI	DVR SPM	23	21	1	0.56	2.27	Small	L

Population: total number of patients and healthy controls considered in the study. Method: quantitative method applied in the study. Cohort investigated: number of patients considered for sensitivity and specificity estimations. Followup: duration of observational period (for early diagnosis study). Sensitivity and specificity: results of the study. LHR+: likelihood ratio. Increase in the LHR+: increase in the probability of the likelihood of the disease. GRADE: results of GRADE evaluation. Quality of evidence was evaluated based on LHR+ values, LHR+ increase probability, and size of the sample included.
Abbreviations: AD: Alzheimer’s disease; FTD: frontotemporal dementia; MCI: mild cognitive impairment; ODD: other dementia; LBD: Lewy body dementia; VaD: vascular dementia; HC: healthy controls.